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| 2008 | | | | Publications | - Mark I. McCarthy, Gonsalo R. Abecasis, Lon R. Cardon, David B. Goldstein, Julian Little, John P. A. Ioannidis, Joel N. Hirschhorn. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature Reviews Genetics 9, 356 - 369 (01 May 2008), doi: 10.1038/nrg2344, Review
- Kovacikova M, Vitkova M, Klimcakova E, Polak J, Hejnova J, Bajzova M, Kováčova Z, Viguerie N, Langin D, Stich V.Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction.Eur J Clin Invest. 2008 Jul;38(7):516-22.
- Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kováciková M, Kovacova Z, Hejnova J, Stich V, Valet P.Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.Eur J Endocrinol. 2008 Jun;158(6):905-10. Epub 2008 Apr 7.
- Bajzová M, Kovaciková M, Vitková M, Klimcaková E, Polak J, Kovacová Z, Viguerie N, Vedral T, Mikulášek L, Sramková P, Srp A, Hejnová J, Langin D, Stich V. Retinol -binding protein 4 expression in visceral and subcutaneous fat in human obesity.Physiol Res. 2007 Nov 30.
- Mazzucotelli, A., Viguerie, N., Tiraby, C., Annicotte, J.S., Mairal, A., Klimcakova, E., Lepin, E., Delmar, P., Dejean, S., Tavernier, G., Lefort, C., Hidalgo, J., Pineau, T., Fajas, L., Clement, K., and Langin, D. 2007. The Transcriptional Coactivator PGC-1 and the Nuclear Receptor PPAR Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPAR Activation in Human White Adipocytes. Diabetes 56:2467-2475.
- Luridsen M, Maher AD, Keun H, Lindon J, Nicholson JK, Nyberg N, Hansen S, Cornett C, Jaroszewski J (2008) Application of the FLIPSY Pulse Sequence for Increased Sensitivity in 1H NMR-based Metabolic Profiling Studies, Anal Chem, 803365-71.
- Persson, A., Hober, S. & Uhlén, M. (2006) A human protein Atlas based on Antibody Proteomics, Current Opinion in Molecular Therapeutics, 8, 185-190
- Larsson, K., Wester, K., Nilsson, P., Uhlén, M., Hober, S., & Wernéus, H. (2006) Multiplexed PrEST immunization for high-throughput affinity proteomics, J Immunol Methods, 315, 110-120
- Falk, R., Ramström, M., Ståhl, S. & Hober, S. (2007) Approaches for Systematic Proteome Exploration, Biomolecular Engineering, 24, 155-168
- Schwenk J, Gry M, Rimini R, Uhlén M, Nilsson P. Antibody Suspension Bead Arrays within Serum Proteomics. J Proteome Res. 2008 Aug;7(8):3168-79.
- Capel, F., Viguerie, N., Vega, N., Dejean, S., Arner, P., Klimcakova, E., Martinez, J.A., Saris, W.H., Holst, C., Taylor, M., Oppert, J.M., Sorensen, T., Clement, K., Vidal, H., and Langin, D. 2008. Contribution of Energy Restriction and Macronutrient Composition to Changes in Adipose Tissue Gene Expression during Dietary Weight-Loss Programs in Obese Women. J Clin Endocrinol Metab in press.
- Michaela Vitkova 1,2,3, Jan Polak 1,2,6, Jindra Vrzalova5, Eva Klimcakova1,2,3, Michaela Kovacikova1,2, Zuzana Kovacova1,2, Lenka Rossmeislova1,2,3, Zuzana Hněvkovská1,2,6, Dominique Langin1,3,4,7, Vladimir Stich . Effect of hyperinsulinemia and weight loss on interstitial levels of cytokines in subcutaneous adipose tissue. J. Clin. Endocrinol. Metab. (submitted)
- Viguerie N. Microarray in inflammation. Series Progress in Inflammation Research.Edited by A. Bosio and B. Gerstmayer, Oct 2008. Section Adipose tissue. . (submitted)
- Kovacikova, M., Vitkova, M., Klimcakova, E., Polak, J., Hejnova, J., Bajzova, M., Kovacova, Z., Viguerie, N., Langin, D., and Stich, V. 2008. Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction. Eur J Clin Invest 38:516-522. . (submitted)
- Holmes, E. Wilson, I.D. and Nicholson, J.K. (2008). Metabolic Phenotypes in Health and Disease. Cell 134 714-717.
- Maher AD, Crockford D, Toft H, Malmodin D, Faber JH, McCarthy MI, Barrett A, Allen M, Walker M, Holmes E, Lindon JC and Nicholson JK (2008) Optimized Acquisition and Processing of 1H NMR Data from Human Plasma for High-throughput Metabolic Phenotyping and Detection of Insulin Resistance related to Type II Diabetes. Anal Chem, In press
- Crockford D, Maher AD, Kourosh A, Barrett A, Plumb R, Wilson I, and Nicholson JK (2008) 1H NMR and UPLC-MSE Statistical HeterospectroscopY (SHY): Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies. Anal Chem, in press.
- Dejeux, E., El abadaloui, H., Gut, I.G. and Tost, J. Identification and quantitative analysis of differentially methylated loci by the PyrosequencingTM technology. Methods Mol Biol 507, in press.
- Grönwall, C., Sjöberg, A., Ramström, M., Höidén-Guthenberg, I., Hober, S., Jonasson, P. & Ståhl, S. (2007) Affibody-mediated transferrin depletion for proteomics applications, Biotechnology J, In press
- Paavilainen, L., Wernérus, H., Nilsson, P. Uhlén, M., Hober, S., Wester, K & Pontén, F (2008) Evaluation of mono-specific antibodies: A comparison study with commercial analogues using immunohistochemistry on tissue microarrays, Appl. Immunohistochem. & Molecular Morphology, Aug
- Ramström, M., Zuberovic, A., Grönwall, C., Hanrieder, J., Bergquist, J. & Hober, S. (2008) Development of Affinity Columns for the Removal of High-Abundant Proteins in Cerebrospinal Fluid, Biotechn Appl Biochem, Apr 15, E-pub ahead of print
- Eriksson, C., Schwenk, J. & Hober, S., (2008) Parallelized high throughput depletion of serum samples based on Affibody molecules, manuscript in preparation
- Rimini R, Schwenk JM, Sjöberg R, Sundberg M, Gry M, Klevebring D, Neiman M, Igel U, Uhlén M and Nilsson P. Validation of multiplex biomarker screening in serum using dual antibody array platforms. manuscript in preparation
- Schwenk J, Igel U, Neiman M, Uhlén M, and Nilsson P, Systematic implementation of antibodies into array-based plasma proteomics. manuscript in preparation
| | | | Presentations | - 16th European Congress on Obesity, Genève (May 2008)
- 44th Annual meeting of the EASD, Roma, (Seprember 2008)
- 1st Central European Congress on Obesity ,Karlovy vary (September 2008)
- Congress of The Czech Society for Diabetes, April 2008
- Congress of the Czech Socoety for Atherosclerosis (December 2007)
- 2nd International Graz Symposium on Lipid and Membrane Biology: Focus on Lipotoxicity (March 2008)
- 16th European Congress on Obesity, Genève (May 2008)
- Printemps de la Cardiologie, Fédération Française de Cardiologie, Groupe de Réflexion sur la Recherche Cardiovasculaire, Société Française de Cardiologie, Montpellier (May 2008)
- Hypertension 2008, European and International Society of Hypertension, Berlin (June 2008)
- Séminaire en endocrinologie, diabétologie et métabolisme du Centre Hospitalier Universitaire du Valais, Lausanne (June 2008)
- 2nd Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN), Geneva (october 2008)
- Seminar series of the Pennington Biomedical Research Center (December 2007)
- Mats Inganäs: Gyrolab®, a generic analysis platform for miniaturized immunoassay. Presentation held at ¨Vårmöte i Klinisk Kemi¨, April 2008, Uppsala Sweden
- The use of genome-wide eQTL associations to identify novel genetic pathways involved in complex traits. American Society of Human Genetics Conference, San Diego, USA, November 2007
- Molecular phenotyping for genomic epidemiology: towards biomarker discovery. NDM, WTCHG, Oxford, February 2008
- Bayesian methods for wavelet analysis of spectral data towards biomarker discovery. Metabomeeting, Lyon, April 2008
- Multivariate molecular phenotypes: statistical methods to expedite genomic epidemiology. ENGAGE WP3 kick-off meeting, June 2008
- A robust statistical method for the detection of alternatively spliced mRNAs from Affymetrix exon arrays. International Biometrics Conference, Dublin, July 2008
- Statistical analysis of proteomic data. International Biometrics Conference, Dublin, July 2008
- The use of genome-wide eQTL associations to identify novel genetic pathways involved in complex traits. Genetic Epidemiology Conference, St Louis, USA, September 2008
| | | | Posters | - Maher AD, Smith LM, Cloarec O, Rantalienen M, Tang H, Elliot P, Stamler, J, Lindon JC, Holmes E and Nicholson JK Statistical Correlation and Projection Methods for Improved Information Recovery from Diffusion-edited NMR Spectra of Biological Samples 49th ENC, Pacific Grove, California, USA.
- HUPO 2008 7th World Congress, Amsterdam, NL 16th – 20th August 2008 Poster“Protein extraction from tissue for mass spectrometry based protein profiling“ Susanne Schwonbeck, Duong Nguyen Thi Thuy, Ivo G. Gut
- Brad Fanger, Jeffrey Bernstein, Gunnar Ekstrand, Therese Eriksson, Maria Schultz, Mats Inganäs. Increased sample volume improves ability to quantify cytokines in Gyrolab Bioaffy 1000. Biomarker World Congress, May 19-21, 2008, San Francisco, US
- Mats Inganäs: Gyrolab® is a versatile and powerful bioanalytical platform for monitoring the development of therapeutic monoclonal antibodies 4th Annual Process International. April 2008, Vienna, Austria
- Josefin Bolik: Gyrolab® is a versatile and powerful bioanalytical platform for monitoring the development of therapeutic monoclonal antibodies. Antibody Discovery and Development Forum, April 2008, Amsterdam, The Netherlands
- Antibody suspension bead arrays - An application for serum and plasma analysis within antibody proteomics J.M. Schwenk, M. Gry, R. Rimini, U. Igel, M. Neiman, M. Uhlén, and P. Nilsson Poster at HUPO 2008, Amsterdam (August 2008)
- SIMBIOMS. Poster presentation. Maria Krestyaninova, Edgars Celms, Martins Opmanis, Karlis Podnieks, Peteris Rucevskis, Andris Zarins, Natalja Kurbatova, Sudeshna Guha Neogi, Juris Viksna, Alvis Brazma, Ugis Sarkans. 11th International meeting of MGED, Riva del Garda, Italy, September 2008.
- SIMBIOMS: an integrated software system for managing information in biomedical studies. Poster presentation. Juris Viksna, Maria Krestyaninova, Karlis Podnieks, Peteris Rucevskis, Andris Zarins, Natalja Kurbatova, Sudeshna Guha Neogi, Alvis Brazma, Ugis Sarkans. ECCB 2008, Cagliari, September 2008.
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