Overview
The MolPAGE consortium’s activities are organized into the 12 workpackages (WP) shown in the figure below. Operationally, these work packages fall into four main areas:
- ‘Sample-Related’ (WP1); to evaluate sample collection and storage methodologies, understand sources of technical and biological variation and explore issues of analyte stability, so as to inform ongoing and future endeavours in biobanking and biomarker discovery;
- ‘Technology-Related’ (WP2-7 and WP10); to develop, upscale and validate tools that will allow molecular phenotyping at an epidemiologic scale including the capacity to undertake analysis of: (a) small molecules (metabonomics); (b) mRNA (transcript profiling); (c) proteins and peptides; (d) DNA methylation patterns; and (e) genome sequence variation;
- ‘Informatics and Analysis’ (WP8 and WP9); to develop bioinformatic tools and statistical methods to support the storage, interrogation and analysis of the large complex data sets produced;
- ‘Training and Management’ (WP11 and WP12)
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